Here is a picture from Isabel’s slide this week, from her project on the pharmacogene ADCY9, from a collaboration with Marie-Pierre Dubé’s and Jean-Claude Tardif’s teams.
Genome-wide association studies have revealed associations between polymorphisms in ADCY9 and response to the drug dalcetrapib, an inhibitor of the CETP protein which increases the serum levels of HDL-C. Other SNPs within ADCY9 have been associated with various phenotypes such as asthma, obesity and malaria. It seems like a good candidate for pleiotropy!
In Isabel’s project, pharmacogenomics meets population genetics meets transcriptomics! We are excited about the results and Peruvians are standing out!