2021

Hamelin D, Fournelle D, Grenier JC, Schockaert J, Kovalchik K, Kubiniok P, Mostefai F, Duquette JD, Saab F, Sirois I, Smith MA, Pattijn S, Soudeyns H, Decaluwe H, Hussin JG*, Caron E* (*co-senior). The mutational landscape of SARS-CoV-2 variants diversifies T cell targets in an HLA supertype-dependent manner. Cell Systems.

Gamache I, Legault MA, Grenier JC, Sanchez R, Rhéaume E, Asgari S, Barhdadi A, Feroz Zada Y, Trochet H, Luo Y, Lecca L, Murray M, Raychaudhuri S, Tardif JC, Dubé MP, Hussin JG*. 2021. A sex-specific evolutionary interaction between ADCY9 and CETP. eLife (*corresponding)

Ben Ali W°, Pesaranghader A°, Avram R, Overtchouk P, Perrin N, Laffite S, Cartier R, Ibrahim, R, Modine T*, Hussin JG*. 2021. Implementing Machine Learning in Interventional Cardiology: The Benefits are Worth the Trouble. Frontiers in Cardiovascular Medicine. (°co-first authors, *co-senior)

Paré B, Rozendaal M, Morin S, Kaufmann L, Simpson SM, Poujol R, Mostefai F, Grenier JC, Xing H, Sanchez M, Yechouron A, Racette R, Hussin JG, Wolf G, Pavlov I, Smith MA. 2021. Patient health records and whole viral genomes from an early SARS-CoV-2 outbreak in a Quebec hospital reveal features associated with favorable outcomes. PLoS ONE

Kuchroo M, Huang J, Wong P, Grenier JC, Shung D, Tong A, Lucas C, Klein J, Burkhardt D, Gigante S, Godavarthi A, Israelow B, Mao T, Eun Oh J, Silva J, Takahashi T, Odio CD, Casanovas-Massana A, Fournier J, Yale IMPACT Team, Farhadian S, Dela Cruz C, Ko AI, Wilson FP, Hussin JG*, Wolf G*, Iwasaki A*, Krishnaswamy S*. Multiscale PHATE Exploration of SARS-CoV-2 Data Reveals Multimodal Signatures of Disease. Nature Biotechnology. (in press) (*co-senior)

Samman K, Mehanna P, Takla E, Grenier JC, Chan MY, Lopes RD, Lee Neely M, Wang TY, Newby LK, Becker RC, Lordkipanidzé M, Ruiz M, Hussin JG°,* and Jolicoeur ME°. 2021. Differential modulation of polyunsaturated fatty acids in patients with myocardial infarction treated with ticagrelor or clopidogrel. Cell Reports Medicine, 2, 1002999 (°co-senior, *corresponding)

Dubé MP, Lemaçon A, Barhdadi A, Lemieux Perreault LP, [25 authors], Hussin JG, Boivin G, Busseuil D, Tardif JC. 2021. Genetics of symptom remission in outpatients with COVID-19. Scientific Reports, 11,10847

Tremblay J, Haloui M, Attaoua R, Tahir R, Hishmih C, Harvey F, Marois-Blanchet FC, Long C , Simon P, Santucci L, Hizel C, Chalmers J, Marre M, Harrap S, Cífková R, Krajčoviechová A, Matthews D, Williams B, Poulter N, Zoungas S, Colagiuri S, Mancia G, Grobbee DE, Rodgers A, Liu L, Agbessi M, Bruat V, Favé M-J, Harwood M, Awadalla P, Woodward M, Hussin JG, Hamet P. 2021. Polygenic risk scores predict diabetes complications and their response to intensive blood pressure and glucose control. Diabetologia.

2020

Tremblay-Gravel M, Fortier A, Baron C, Mehanna P, Ducharme A, Hu Q, Hussin JG, Tardif JC, Des Rosiers C, Dupuis J, Ruiz M. 2020 Long-chain acylcarnitines and monounsaturated fatty acids discriminate heart failure patients according to pulmonary hypertension status. Metabolites. 11(4), 196

Pesaranghader A, Pelletier J, Grenier JC, Poujol R, Hussin JG*. 2020. ImputeCoVNet: 2D ResNet Autoencoder for Imputation of SARS-CoV-2 Sequences. 15th Machine Learning in Computational Biology (MLCB) proceedings. (*corresponding)

Hamet P, Pausova Z, Attaoua R, Hishmih C, Haloui M, Shin J, Paus T, Michal A, Gaudet D, Santucci L, Kotchen T. A., Cowley A.W, Hussin JG, Tremblay J. 2020. SARS-CoV-2 receptor ACE2 gene is associated with hypertension and severity of COVID-19 interaction with sex, obesity and smoking. American Journal of Hypertension.

2019

Rochefort-Boulanger C, Choiniere L, Grenier JC, Carrier PL and Hussin JG*. 2019. Generalization Capability of the Diet Network Model on Genomic Data. 14th Machine Learning in Computational Biology (MLCB) proceedings  (*corresponding)

2018

Hilary C Martin*, Elizabeth M Batty*, Julie G Hussin*, Portia Westall, Tasman Daish, Stephen Kolomyjec, Paolo Piazza, Rory Bowden, Margaret Hawkins, Tom Grant, Craig Moritz, Frank Grutzner, Jaime Gongora, Peter Donnelly. (2018) Insights into platypus population structure and history from whole-genome sequencing. Molecular biology and evolution. (*co-first)

2017

Isabel Alves, Armande Ang Houle, Julie G Hussin, Philip Awadalla. (2017) The impact of recombination on human mutation load and disease. Phil. Trans. R. Soc. B.

Adriana Romero, Pierre Luc Carrier, Akram Erraqabi, Tristan Sylvain, Alex Auvolat, Etienne Dejoie, Marc-André Legault, Marie-Pierre Dubé, Julie G Hussin, Yoshua Bengio. (2016) Diet networks: thin parameters for fat genomics. 5th International Conference on Learning Representations (ICLR) 2017.

2016

Benjamin Davies, Edouard Hatton, Nicolas Altemose, Julie G Hussin, Florencia Pratto, Gang Zhang, Anjali Gupta Hinch, Daniela Moralli, Daniel Biggs, Rebeca Diaz, Chris Preece, Ran Li, Emmanuelle Bitoun, Kevin Brick, Catherine M Green, R Daniel Camerini-Otero, Simon R Myers, Peter Donnelly. (2016) Re-engineering the zinc fingers of PRDM9 reverses hybrid sterility in mice. Nature.

2015

Hilary C Martin, Ryan Christ, Julie G Hussin, Jared O’Connell, Scott Gordon, Hamdi Mbarek, Jouke-Jan Hottenga, Kerrie McAloney, Gonnecke Willemsen, Paolo Gasparini, Nicola Pirastu, Grant W Montgomery, Pau Navarro, Nicole Soranzo, Daniela Toniolo, Veronique Vitart, James F Wilson, Jonathan Marchini, Dorret I Boomsma, Nicholas G Martin, Peter Donnelly. (2015) Multicohort analysis of the maternal age effect on recombination. Nature communications.

Julie G Hussin, Alan Hodgkinson, Youssef Idaghdour, Jean-Christophe Grenier, Jean-Philippe Goulet, Elias Gbeha, Elodie Hip-Ki, Philip Awadalla. (2015) Recombination affects accumulation of damaging and disease-associated mutations in human populations. Nature genetics.

2014

Benjamin Davies, Edouard Hatton, Julie Hussin, Nicolas Altemose, Florencia Pratto, Daniela Moralli, Anjali Gupta, Daniel Biggs, Kevin Brick, Catherine Green, Daniel Camerini-Otero, Simon Myers, Peter Donnelly. (2014) Reprogramming meiotic recombination in the mouse. TRANSGENIC RESEARCH.

2013

Ferran Casals, Alan Hodgkinson, Julie Hussin, Youssef Idaghdour, Vanessa Bruat, Thibault de Maillard, Jean-Cristophe Grenier, Elias Gbeha, Fadi F Hamdan, Simon Girard, Jean-François Spinella, Mathieu Larivière, Virginie Saillour, Jasmine Healy, Isabel Fernández, Daniel Sinnett, Jacques L Michaud, Guy A Rouleau, Elie Haddad, Françoise Le Deist, Philip Awadalla. (2013) Whole-exome sequencing reveals a rapid change in the frequency of rare functional variants in a founding population of humans. PLoS Genetics.

Marc-Phillip Hitz, Louis-Philippe Lemieux-Perreault, Christian Marshall, Yassamin Feroz-Zada, Robbie Davies, Shi Wei Yang, Anath Christopher Lionel, Guylaine D’Amours, Emmanuelle Lemyre, Rebecca Cullum, Jean-Luc Bigras, Maryse Thibeault, Philippe Chetaille, Alexandre Montpetit, Paul Khairy, Bert Overduin, Sabine Klaassen, Pamela Hoodless, Philip Awadalla, Julie Hussin, Youssef Idaghdour, Mona Nemer, Alexandre FR Stewart, Cornelius Boerkoel, Stephen W Scherer, Andrea Richter, Marie-Pierre Dubé, Gregor Andelfinger. (2013) Rare Copy Number Variants Contribute to Congenital Left-Sided Heart Disease. PLoS Genetics.

2012

Julie Hussin, Daniel Sinnett, Ferran Casals, Youssef Idaghdour, Vanessa Bruat, Virginie Saillour, Jasmine Healy, Jean-Christophe Grenier, Thibault De Malliard, Jean-Francois Spinella, Mathieu Lariviere, Stephan Busche, Greg Gibson, Anna Andersson, Linda Holmfeldt, Jing Ma, Lei Wei, Jinghui Zhang, Gregor Andelfinger, James Downing, Charles Mullighan, Phillip Awadalla. (2012) Rare allelic forms of PRDM9 associated with childhood leukemogenesis. Genome Research.

Ferran Casals, Youssef Idaghdour, Julie Hussin, Philip Awadalla. (2012) Next-generation sequencing approaches for genetic mapping of complex diseases. Journal of Neuroimmunology.

Reed A Cartwright, Julie Hussin, Jonathan EM Keebler, Eric A Stone, Philip Awadalla. (2012) A family-based probabilistic method for capturing de novo mutations from high-throughput short-read sequencing data. Statistical applications in genetics and molecular biology.

2011

Julie Hussin, Marie-Hélène Roy-Gagnon, Roxanne Gendron, Gregor Andelfinger, Philip Awadalla. (2011) Age-dependent recombination rates in human pedigrees. PLoS Genetics.

Rachel A Myers, Ferran Casals, Julie Gauthier, Fadi F Hamdan, Jon Keebler, Adam R Boyko, Carlos D Bustamante, Amelie M Piton, Dan Spiegelman, Edouard Henrion, Martine Zilversmit, Julie Hussin, Jacklyn Quinlan, Yan Yang, Ronald G Lafrenière, Alexander R Griffing, Eric A Stone, Guy A Rouleau, Philip Awadalla. (2011) A population genetic approach to mapping neurological disorder genes using deep resequencing. PLoS Genetics.

Julie Hussin, Philippe Nadeau, Jean-François Lefebvre, Damian Labuda. (2011) Haplotype allelic classes for detecting ongoing positive selection. BMC Bioinformatics.

2010

OraLee H Branch, Patrick L Sutton, Carmen Barnes, Juan Carlos Castro, Julie Hussin, Philip Awadalla, Gisely Hijar. (2010) Plasmodium falciparum genetic diversity maintained and amplified over 5 years of a low transmission endemic in the Peruvian Amazon. Molecular biology and evolution.

Duane L Guernsey, Haiyan Jiang, Julie Hussin, Marc Arnold, Khalil Bouyakdan, Scott Perry, Tina Babineau-Sturk, Jill Beis, Nadine Dumas, Susan C Evans, Meghan Ferguson, Makoto Matsuoka, Christine Macgillivray, Mathew Nightingale, Lysanne Patry, Andrea L Rideout, Aidan Thomas, Andrew Orr, Ingrid Hoffmann, Jacques L Michaud, Philip Awadalla, David C Meek, Mark Ludman, Mark E Samuels. (2010) Mutations in centrosomal protein CEP152 in primary microcephaly families linked to MCPH4. The American Journal of Human Genetics.