Julie Hussin

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Dr. Julie Hussin is an IVADO assistant professor in the Department of Medicine, Université de Montréal, and FRQS Junior 1 researcher. She leads the bioinformatics group MHI-OMICS at the Montreal Heart Institute (MHI). Julie is trained in computational biology,  with a strong interest in population genetics, biomedical research and deep learning methods.

Before coming to the MHI, she was a Human Frontiers postdoctoral fellow in Peter Donnelly‘s group at the Wellcome Trust Centre for Human Genetics, University of Oxford, and a visiting fellow at the McGill University and Genome Quebec Innovation Centre. From 2009 to 2013, she did her Ph.D. with Philip Awadalla at Sainte-Justine Hospital Research Centre.

Contact : julie.hussin [at] umontreal.ca
Address : 5000 Bélanger, Room S-1450.
Phone : 514 376-3330 #2028

Representative Publications

Gamache I, Legault MA, Grenier JC, Sanchez R, Rhéaume E, Asgari S, Barhdadi A, Feroz Zada Y, Trochet H, Luo Y, Lecca L, Murray M, Raychaudhuri S, Tardif JC, Dubé MP, Hussin JG*. 2021. A sex-specific evolutionary interaction between ADCY9 and CETP. eLife (*corresponding)

Hamelin D, Fournelle D, Grenier JC, Schockaert J, Kovalchik K, Kubiniok P, Mostefai F, Duquette JD, Saab F, Sirois I, Smith MA, Pattijn S, Soudeyns H, Decaluwe H, Hussin JG*, Caron E* (*co-senior). The mutational landscape of SARS-CoV-2 variants diversifies T cell targets in an HLA supertype-dependent manner. Cell Systems.

Ben Ali W°, Pesaranghader A°, Avram R, Overtchouk P, Perrin N, Laffite S, Cartier R, Ibrahim, R, Modine T*, Hussin JG*. 2021. Implementing Machine Learning in Interventional Cardiology: The Benefits are Worth the Trouble. Frontiers in Cardiovascular Medicine. (°co-first authors, *co-senior)

Samman K, Mehanna P, Takla E, Grenier JC, Chan MY, Lopes RD, Lee Neely M, Wang TY, Newby LK, Becker RC, Lordkipanidzé M, Ruiz M, Hussin JG°,* and Jolicoeur ME°. 2021. Differential modulation of polyunsaturated fatty acids in patients with myocardial infarction treated with ticagrelor or clopidogrel. Cell Reports Medicine, 2, 1002999 (°co-senior, *corresponding)

Romero A, Carrier PL, Erraqabi A, Sylvain T, Auvolat A, Dejoie E, Legault MA, Dubé MP, Hussin JG, Bengio Y. (2016) Diet networks: thin parameters for fat genomics. 5th International Conference on Learning Representations (ICLR) 2017.

Davies B, Hatton EW, Altemose N, Hussin JG, Pratto F, Zhang G, Moralli D, Hinch AG, Biggs D, Diaz R, Preece C, Brick K, Green C, Camerini-Otero RD, Myers SR, Donnelly P. Re-engineering the zinc fingers of Prdm9 reverses hybrid sterility in mice. Nature 2016 doi :10.1038/nature16931

Hussin JG, Hodgkinson A, Idaghdour Y, Grenier JC, Goulet JP, Gbeha E, Hip-Ki E, Awadalla P. Recombination affects accumulation of damaging and disease-associated mutations in human populations. Nature Genetics 2015 doi :10.1038/ng.3216

Hussin J., Sinnett D., Casals F. Idaghdour Y, Bruat V, Saillour V, Healy J, Grenier JC, de Malliard T, Busche S, Spinella JF, Lariviere M, Gibson G, Andersson A, Holmfeldt L, Ma J, Wei L, Zhang J, Andelfinger G, Downing JR, Mullighan CG, Awadalla P. Rare allelic forms of PRDM9 associated with childhood leukemia. Genome Res. 2013 Mar;23(3) :419-30. doi : 10.1101/gr.144188.112.

Cartwright R., Hussin J., Keebler J., Stone E., and Awadalla P. A family-based probabilistic method for capturing de novo mutations from high-throughput short-read sequencing data. J Stat Appl Genet Mol Biol. 2012. Vol. 11 Iss. 2, Article 6.

Hussin J., Lefebvre J-F., Nadeau P. and Labuda D. 2010. Haplotype allelic classes for detecting ongoing positive selection. BMC Bioinformatics 11:65

(Full list here)

Expert comments

2016/09  – Québec Science, Podcast: Effet fondateur: l’héritage des pionniers, épisode 6. Interview par Sylvain Lumbroso. September 21, 2016.

2015/02  – Oxford Science Blog, Making sense of sex: why genes recombine. Interviewed by Charvy Narain. 23 February, 2015

2014/10  – Nature Video, Lindau collection: May cause drowsiness with Martin Evans and Oliver Smithies, Interviewed by Lorna Stewart. October 8, 2014.

2013/11  – Radio-Canada International, Le Québec est un incroyable laboratoire génétique, Interviewed by Adrian Lachance. 13 November, 2013.

2012/12  – Radio-Canada International, Cancers pédiatriques, avancée majeure dans le domaine de la recherche, Interviewed by Anne-Marie Yvon. 18 December, 2012.